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Asthma Drug Linked to Deadly Events

Posted by Administrator (admin) on Jul 18 2008 at 4:45 PM
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Patients with chronic asthma who daily take the asthma drug “Serevent” (generic Salmeterol) are at high risk of suffering from serious adverse events including death, some researchers revealed.

As part of the research, a 12-week assessment of 32 clinical trials that involved 62,630 patients was conducted.  The research findings not only pointing to serious adverse events with daily Serevent use, but also imply that the collaborative use of inhaled corticosteroids with Serevent may help decrease such distasteful effects. However, the researchers are not damn sure if the addition of corticosteroids with Serevent reduces the risk completely.

“We found that the biggest increase in risk was seen in people with asthma who were not taking inhaled corticosteroids; however, there is no guarantee that inhaled corticosteroids abolish the risk altogether,” said Dr. Christopher Cates, lead researcher from Community Health Sciences at St. George’s, London.

In the review conducted as part of the studies, participants were randomly assigned to either regular Serevent, a placebo, or the medication Salbutamol. 2380 of all the patients involved were children.

After analyzing data from two large surveillance studies, the researcher discovered that that regular Serevent use increased the risk of asthma-related mortality in patients who did not also use inhaled steroids. Additionally, the mortality from any cause was higher with Serevent than with placebo. Serevent did increase the risk of non-fatal serious events.  The researchers evaluate that one further severe event arose over 28 weeks for every 188 patients who used Serevent on a daily basis.  Additional research is required to conclude if Serevent use is more or less risky in children as compared with adults.


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